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2022年06月05日 12:01:52 No.21500

ronequir

投稿者 : ronequir [URL]

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The nucleolus is an important target for anticancer drug development. However, methods for monitoring drug effects on this target are time consuming and require multiple experiments for detailed analysis of nucleolar changes. We developed Nucleolar Chromatin Index (NCI), a simple and fast approach to assess the effect of a drug on the nucleolar chromatin organization, including the number and size of nucleoli of different cell types. Traditional morphological analysis to evaluate cell composition in a nucleus/nucleolus ratio is based on simple counting of approx. 50 cells of various cell types. However, this method potentially suffers from observer bias, ec5d62056f ronequir
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